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doi:10.1016/j.clinthera.2011.05.088

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Route of Administration How a peptide is delivered dramatically affects how long it stays in the body: Subcutaneous injection : slower absorption, longer duration Intramuscular injection : faster peak concentration, moderate duration Oral and intranasal peptides : often rapidly broken down, requiring protective technologies or higher doses For example, oral BPC-157 may work primarily through gut-localized pathways, while injectable versions may provide broader systemic benefits

The most important caveat is that all CNS evidence is preclinical

NTZ at both doses significantly enhanced hepatic GSH levels as well as SOD activity with a more pronounced effect with the higher dose, compared to the MTX group

Physiol Res 2007